Joel Krier, MD, MMSc, FACMG

Photo of Joel Krier, MD, MMSc, FACMG
Associate Professor, Medical Director
Genetic Counseling

Joel Krier, MD, MMSc, FACMG, is Associate Professor in the School of Health and Rehabilitation Sciences and Medical Director of the Master of Science in Genetic Counseling program at MGH Institute of Health Professions.

Dr. Krier is Clinical Chief of the Division of Genetics at Brigham & Women’s Hospital, Director of Brigham Genomic Medicine, and Assistant Professor, Medicine, at Harvard Medical School. Dr. Krier is an investigator on the NIH Undiagnosed Diseases Network Project and past co-investigator on the NIH-funded MedSeq and ClinGen Projects, internationally known genomic medicine initiatives.

Research Interests


Dr. Krier's research interests include rare disease genetics, gene disease association discovery, genomic sequencing analysis, and clinical implementation of genomic sequencing.



BA, BM (double degree program), Neuroscience, Saxophone Performance, Oberlin College and Conservatory of Music, Oberlin, OH
MD, Medicine, University of Pittsburgh, Pittsburgh, PA
MMSc, Biomedical Informatics, Harvard Medical School, Boston, MA


Vassy JL, Christensen KD, Schonman EF, Blout CL, Robinson JO, Krier JB, Diamond PM, Lebo M, Machini K, Azzariti DR, Dukhovny D, Bates DW, MacRae CA, Murray MF, Rehm HL, McGuire AL, Green RC; "MedSeq Project. The Impact of Whole-Genome Sequencing on the Primary Care and Outcomes of Healthy Adult Patients: A Pilot Randomized Trial." Ann Intern Med. 2017 Jun 27. doi: 10.7326/M17-0188. [Epub ahead of print] PubMed PMID: 28654958.

Vassy JL, Christensen KD, Schonman EF, Blout CK, Robinson JL, Krier J, Diamond PM, Lebo M, Machini K, Azzariti DR, Dukhovny D, Bates D, MacRae CA, Murray MF, Rehm HL, McGuire AL, Green RC for the MedSeq Project. "The impact of genome sequencing on the primary care outcomes of healthy adult patients. A pilot randomized trial." Ann Int Med. 2017;167(3):159-169.

Krier J, Kalia S, Green RC. "Genomic Sequencing in Clinical Practice: Applications, Challenges and Opportunities." Dialogues in Clinical Neuroscience. 2016. Sept. 18(3):299-312.  PubMed.

Krier J, Barfield R, Green RC, Kraft P. "Reclassification of genetic-based risk predictions as GWAS data accumulate." Genome Med. 2016 Feb; 8(1):20. PubMed


Krier J, Blout C, Lautenbach D, Vassy J, Robinson J, Helm M, Lee K, Murray M, Green R. "Communication and management of genomic sequencing results by non-geneticist physicians." American Society of Human Genetics, Annual Meeting. (Platform Presentation) October, 2015. Baltimore, MD.

Curriculum Vitae