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Meetu Kaushik, PhD

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Term Lecturer

Dr. Kaushik has a PhD in Cell and Molecular Biology. After her PhD she joined National Institute for Health and Medical Research (INSERM)in Paris as a Postdoctoral fellow. Her research involved the study of transferrin receptor in erythropoiesis and IgA Nephropathy, a kidney disease. As a Research Scientist at Yale University her research projects are focused on triplex induced DNA damage resulting in apoptosis, the mechanism involved and their therapeutic approach in cancer cells.

She served as an editor in peer-reviewed journals and as judge national conferences for undergraduate research. She has taught and mentored undergraduate and graduate students as a biochemistry and cell and molecular biology professor.

 

Publications

Meetu Kaushik Tiwari, Nneoma Adaku, N Peart and Faye A Rogers. Triplex Structures Induce DNA Double-Strand Breaks Via Replication Fork Collapse in NER Deficient Cells. Nucleic Acid Res.2016 44 (16), 7742-7754.

Nneoma Adaku, Hyun Bong Park, Daniel J. Spakowicz, Meetu Kaushik Tiwari, Scott A. Strobel, Jason M. Crawford*, and Faye A. Rogers*. A DNA Repair Inhibitor Isolated from an Ecuadorian Fungal Endophyte Exhibits Synthetic Lethality in PTEN-Deficient Glioblastoma. J. Nat. Prod. 2020, 83, 6, 1899–1908.

Meetu Kaushik Tiwari and Faye A Rogers. XPD-dependent activation of apoptosis in response to triplex-induced DNA damage. Nucleic Acids Res. 2013 Oct; 41(19):8979-94.

Faye A Rogers, Janice A Lloyd and Meetu Kaushik Tiwari. Improved bioactivity of G-rich triplex forming oligonucleotides containing modified guanine bases. Artif DNA PNA XNA. 2014 Jan 22;5(1)

Faye A Rogers and Meetu Kaushik Tiwari. Triplex-induced DNA damage response. Yale J Biol Med.2013 Dec 13; 86(4):471-8.

Séverine Coulon, Michaël Dussiot, Damien Grapton, Thiago Trovati Maciel, Pamella Huey Mei Wang, Celine Callens, Meetu Kaushik Tiwari, Saurabh Agarwal, Aurelie Fricot, Julie Vandekerckhove, Houda Tamouza, Yael Zermati, Jean-Antoine Ribeil, Kamel Djedaini, Zeliha Oruc, Virginie Pascal, Geneviève Courtois, Bertrand Arnulf, Marie-Alexandra Alyanakian, Patrick Mayeux, Tomas Leanderson, Marc Benhamou, Michel Cogné, Renato C Monteiro, Olivier Hermine, Ivan C Moura. Polymeric IgA1 controls erythroblast proliferation and accelerates erythropoiesis recovery in anemia (2011). Nature Medicine Oct 23; 17(11): 1456-65.

Presentations

Faye A. Rogers, Meetu Kaushik. Gene-targeted apoptosis as a novel therapeutic strategy for HER2-positive breast cancer. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl): Abstract nr 4773.